Hindrance of the Proteolytic Activity of Neutrophil-Derived Serine Proteases by Serine Protease Inhibitors as a Management of Cardiovascular Diseases and Chronic Inflammation

Burster, Timo and Mustafa, Zhadyra and Myrzakhmetova, Dinara and Zhanapiya, Anuar and Zimecki, Michal (2021) Hindrance of the Proteolytic Activity of Neutrophil-Derived Serine Proteases by Serine Protease Inhibitors as a Management of Cardiovascular Diseases and Chronic Inflammation. Frontiers in Chemistry, 9. ISSN 2296-2646

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Official URL: https://doi.org/10.3389/fchem.2021.784003

Abstract

During inflammation neutrophils become activated and segregate neutrophil serine proteases (NSPs) to the surrounding environment in order to support a natural immune defense. However, an excess of proteolytic activity of NSPs can cause many complications, such as cardiovascular diseases and chronic inflammatory disorders, which will be elucidated on a biochemical and immunological level. The application of selective serine protease inhibitors is the logical consequence in the management of the indicated comorbidities and will be summarized in this briefing.

Item Type:	Article
Subjects:	Impact Archive > Chemical Science
Depositing User:	Managing Editor
Date Deposited:	29 Nov 2022 04:53
Last Modified:	01 Aug 2025 04:05
URI:	http://content.msforpublish.com/id/eprint/456

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