Divalproex Sodium-Induced Hyponatremia: A Case Report with Positive Rechallenge

This report describes the case of a 56-year-old African American male who experienced severe hyponatremia after receiving Divalproex sodium therapy for bipolar I disorder on various occasions. Divalproex re-initiation caused a recurrence of hyponatremia, leading to discontinuation of the drug and initiation of Lithium. Although most cases of hyponatremia are asymptomatic, a sudden drop in sodium levels can be fatal. Therefore, it is important to be aware of the risk of hyponatremia in individuals undergoing bipolar I disorder therapy with Divalproex. This case highlights the need to monitor sodium levels in patients taking valproic acid.